食管癌术前放化疗疗效分析.docVIP

食管癌术前放化疗疗效分析 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：食管癌术前放化疗疗效分析 1 1 资料与方法 3 2 结果 3 3 讨论 5 文2：食管癌术前放化疗疗效分析 6 1 资料与方法 8 2 结果 8 3 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 食管癌术前放化疗疗效分析 文1：食管癌术前放化疗疗效分析 【Abstract】 Objective To evaluate the tolerance and the short-term outcome of preoperative chemoradiotherapy for patients with locally advanced esophageal carcinoma, to observe effects of preoperative chemoradiotherapy on tumor resection rate, incidence of complicatio after surgery. Methods From December 2000 to August 2002, twenty-Six coecutive patients with locally advanced esophageal carcinomas were entered into this study. Each involved radiotherapy, in a dose of chemotherapy coisted of Paclitaxel and Cisplatin. The chemotherapy was administered in continuous infusion for the fit week and the fourth week. After completion of chemoradiotherapy, clinical restaging was performed. Esophagectomy and lymphadenectomies were performed 4-6 weeks after chemoradiotherapy. Results Twenty-five patients completed the planned chemoradiotherapy. The toxicities of chemoradiotherapy such as myelotoxicity, pulmonary toxicity, esophagitis were grade I or II. The pathological complete respoe rate was %, the three yea survival rate of combine therapy and surgery alone was %,five yea survival rate was % ，the local control ratio was %, the distant metastasis rate was %.The disease free survival（DFS）rate was %.These prognosis facto were found to influence survival in a multivariate analysis: the location of the tumor, the disease stage, the length of the tumor, and the lymphoid node metastasis. Conclusio The results of this study suggest that the strategy of chemoradiotherapy followed by surgery is safe. Preoperative chemoradiotherapy can significantly reduce the tumor stage, and achieve substantially high clinical respoe rate and pathological complete respoe rate. 【Key words】 Esophageal carcinoma surgery radiotherapy chemotherapy 食管癌是我国常见恶性肿瘤之一，其发病率高