左心室流出道电活动改变中的作用.docVIP

左心室流出道电活动改变中的作用 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：左心室流出道电活动改变中的作用 1 1 材料与方法 3 14 标本制备 3 2 结果 5 21 同类型大鼠左心室流出道诱发电位特征 5 3 讨论 6 文2：肾上腺素对离体豚鼠左心室流出道组织自律性电活动的影响 6 1 MATERIALS AND METHODS 7 2 RESULTS 9 3 DISCUSSION 9 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 12 正文 左心室流出道电活动改变中的作用 文1：左心室流出道电活动改变中的作用 【ABSTRACT】 Objective:To study the relatiohip between the electric potential of left ventricular outflow tract (LVOT) and the activity of Na+K+ATPase of LVOT from different kinds of :The activity of Na+K+ATPase of LVOT was measured by the enzymologic method in Wastar rats, SpragueDawley rats, spontaneously hyperteive rats and saline hyperteive rats. The electrophysiological paramete, resting potential (RP), amplitude of action potential (APA), maximal rate of depolarization of phase 0 (Vmax) and duration of action potential (APD) were intracellularlly :There was no significantdifference between spontaneously hyperteive rats (SHR) and Wistar rats in the RP,APA, and Vmax. But in SHR, APD was prolonged, and the activity of Na+K+ATPase was decreased. All paramete were no of significant difference discovered between SD rats and Wistar rats. There was no significant difference between SD rats and saline hyperteive rats (SDSa) in RP and APA. But in SDSa rats, the Vmax was decreased, APD was shortened, and the activity of Na+K+ATPase was decreased. No significant difference was discovered between SDSa and SHR in the activity of Na+K+:The change of electric potential of left ventricular outflow tract from different kinds of rats seems no relatiohip to the activity of Na+K+ATPase. It probably contributes to the permeability of cell membrane. 【KEY WORDS】 Different kinds of rats；Left ventricular outflow tract；Action potential；Na+K+ATPase 心肌肥厚（cardiac hypertrophy）是高血压常见并发症，其发生机制尚不完全清楚。但长期心肌肥厚可引发恶性心律失常发生，为目前导致猝死的主要原因之一[1]。不同类型高血压大鼠心肌肥厚时左心室流出道自发电活动及诱发电位的特征我们已有报道[2,3]，但产生这一变化的基础尚不清楚。Na+K+ATPase做为心肌细胞膜上标志酶，对于维持细胞正常容积及跨膜电位有重要意义。心肌肥厚时其变化是否与电活动有关，少见报道。为此，本实验观察了Wi