芪丹益肾降糖丸对早期糖尿病肾病患者血清转化生长因子β1的影响药学.docVIP

芪丹益肾降糖丸对早期糖尿病肾病患者血清转化生长因子β1的影响药学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：芪丹益肾降糖丸对早期糖尿病肾病患者血清转化生长因子β1的影响药学 1 1 资料与方法 3 2 结果 4 3 讨论 5 文2：芪参益气滴丸对急性心肌梗塞大鼠转化生长因子β1的影响药学 7 1 器材与仪器 8 2 方法 9 3 结果 10 4 讨论 11 参考文摘引言： 14 原创性声明（模板） 16 文章致谢（模板） 16 正文 芪丹益肾降糖丸对早期糖尿病肾病患者血清转化生长因子β1的影响药学 文1：芪丹益肾降糖丸对早期糖尿病肾病患者血清转化生长因子β1的影响药学 Abstract：ObjectiveTo study the effect of Qidanyishenjiangtang Pill on serum traforming growth factor-β1(TGF-β1) in patients with early diabetic nephropathy(EDN).MethodsSixty-one patients with EDN were randomly divided into the control group(n=30) and the treatment group(n=31). The control group was applied regular treatment of Benazepril and the treatment group was added to Qidanyishenjiangtang pill on the basis of regular treatment for 8 weeks. Serum TGF-β1 were determined with ELISA before and after treatment, and fasting blood glucose(FBG), HbAlc,urinary albumin excretion rate (UAER), serum creatinine(Scr), blood lipids were examed as with pretreatment, the serum TGF-β1 level of both groups decreased significantly(P＜) and the difference of two groups was obvious(P＜). The difference between before and after treatment of the level of FBG,HbAlc,UAER,Scr,TC,TG,HDL-C,TGF-β1 were significant(P＜ and P＜).ConclusionQidanyishenjiangtang pill combined with Benazepril can markedly decreased the serum TGF-β1 level of EDN, the effect is better than Benazepril only. Key words： Diabetic nephropathy; Traforming growth factor-β1; Qidanyishenjiangtang pill 糖尿病肾病(diabetic nephropathy，DN)是糖尿病常见而难治的慢性微血管并发症，弥漫性肾小球硬化是糖尿病的特异性肾损害，并已成为导致终末期肾功能衰竭最主要的病因之一，也是DN患者重要的死亡原因。迄今为止DN的发病机制尚未完全明了，涉及了多个方面［1］，如代谢紊乱、血流动力学异常、细胞因子和遗传因素等。近年研究表明，转化生长因子β(traforming growth factor-beta，TGF-β)在DN发病机制中起重要作用［2］，这为本研究提供了重要的理论依据。芪丹益肾降糖丸是治疗DN的临床经验方［3］，具有益气养阴、温肾健脾、活血利水等功效。我们观察了早期糖尿病肾病患者服用芪丹益肾降糖丸治疗前后尿微量蛋白及肾功能、血脂、血清TGFβ1等的变化，旨在探讨芪丹益肾降糖丸对早期DN患者的治疗作用及可能的作用机制。 1 资料与方法 一般资料观察病例共61例，均为我院门诊及住院患者，采用随机对照法分组。芪丹益肾降糖丸组(治疗组)31例，男17例，女14例；平均年龄(±)岁；平均病程(±)年。西药常规组(对照组)30例，男14例，女16例；平均年龄(±)岁；平均病