RANTES403GAMCP12518AG基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性临床医学（行业资料）.docVIP

RANTES403GAMCP12518AG基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性临床医学（行业资料） 文档信息 主题： 关于“行业资料”中“医学资料”的参考范文。 属性： F-01NWKC，doc格式，正文32080字。质优实惠，欢迎下载！ 适用： 作为医学资料、临床医学资料写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：RANTES403GAMCP12518AG基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性临床医学 2 1??对象和方法 3 2??结果 4 3??讨论 5 文2：浅论RANTES403GAMCP12518AG基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性 6 1对象和方法 8 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 RANTES403GAMCP12518AG基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性临床医学（行业资料） 文1：RANTES403GAMCP12518AG基因多态性与呼吸道合胞病毒毛细支气管炎易感性的相关性临床医学 Abstract: ? Objective: To explore the correlation of regulated on activation，normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1(MCP-1) gene polymorphisms with the susceptibility of respiratory syncytial virus (V) bronchiolitis. Methods:?RANTES-403G/A and MCP-1-2518A/G were genotyped with polymerase chain reaction-restriction fragment length polymorphism in 150 children with V bronchiolitis and 120 healthy subjects. Results:The frequency of each genotype for RANTES-403G/A was %?(GG)，%?(GA)，%?(AA) in case group and %?(GG)，%?(GA)，%?(AA) in control one，respectively. There was significant difference between two groups?(P). The frequency of each allele was %(G)，%?(A) in case group，and %(G)，%?(A) in control group. The frequency of A allele was significantly increased in case group?(P);Children carrying with A allele increased risk for V bronchiolitis compared with those with G allele (OR=， P). There were no significant differences for genotype and allele frequency of MCP-1-2518A/G between two groups?(P). Conclusion:?RANTES-403A allele is associated with the susceptibility and may be one of candidate genes for V bronchiolitis. No correlation is found between MCP-1-2518A/G gene polymorphisms and the susceptibility of V bronchiolitis. Key words: ? respiratory syncytial virus;bronchiolitis;gene polymorphisms;regulated on activation，normal T cell expressed and secreted;monocyte chemotactic protein-1 呼吸道合胞病毒(V