内科学教学课件72 Hyperthyroidism.pptVIP

The usual daily maintenance doses of antithyroid drugs in the titration regimen are 2.5 to 10 mg of carbimazole or methimazole and 50 to 100 mg of propylthiouracil. In the block-replace regimen, the initial dose of antithyroid drug is held constant and the dose of levothyroxine is adjusted to maintain normal unbound T4 levels. When TSH suppression is alleviated, TSH levels can also be used to monitor therapy. Maximum remission rates (up to 30 to 50% in some populations) are achieved by 18 to 24 months. For unclear reasons, remission rates appear to vary in different geographic regions.