右归丸对骨髓抑制小鼠骨髓细胞周期和凋亡的影响.docVIP

右归丸对骨髓抑制小鼠骨髓细胞周期和凋亡的影响 文档信息 属性： Doc-03VFKC，doc格式，正文10306字。质优实惠，欢迎下载！ 说明： 作为医药学资料、临床医学资料的写作参考资料，提供解决怎么写及格式等相关问题。 适用： 作为文章写作的参考文献，解决如何写好实用应用文、正确编写文案格式、内容摘取等相关工作。 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：右归丸对骨髓抑制小鼠骨髓细胞周期和凋亡的影响 2 1 材料与方法 3 2 结果 5 3 讨论 5 文2：右归丸对骨髓抑制小鼠骨髓细胞周期和凋亡的影响 7 1 材料与方法 8 2 结果 10 3 讨论 11 参考文摘引言： 13 原创性声明（模板） 14 文章致谢（模板） 15 正文 右归丸对骨髓抑制小鼠骨髓细胞周期和凋亡的影响 文1：右归丸对骨髓抑制小鼠骨髓细胞周期和凋亡的影响 Abstract Objective To study the effect of You Gui Wan on peripheral blood cells， bone marrow cell cycle and apoptosis of myelosuppressed mice and to discuss its possible mechanism in hematopoietic Automatic blood cell analysator， white blood cell counting and flow cytometry (FCM) were applied respectively in detecting the effect of You Gui Wan on peripheral blood cells， bone marrow nucleated cells， bone marrow cell cycle and apoptosis of myelosuppressed Peripheral red blood cells， hemoglobin and bone marrow nucleated cells increased obviously by middle or high dose You Gui Wan; high dose You Gui Wan had significant effect in raising the level of blood platelet and white blood cells; low or high dose You Gui Wan promoted the traition of bone marrow cells from GO/G1 to S phase and that from S phase to G2/M phase， thus led to a higher cell proportion in G2/M phase as well as the proliferation index; middle or low dose You Gui Wan decreased bone marrow apoptosis greatly. Conclusio You Gui Wan may promote the recovery of hemopoietic function of injured bone marrow cells by repairing the damaged DNA and it can accelerate GO/G-S phase and S-G2/M phase traition， activate the proliferation and differentiation， inhibit the apoptosis of hemopoietic cells and regulate the balance between their proliferation and apoptosis。 KEYWORDS You Gui Wan　　　　　　　　 myelosuppression　　　　　　　　 bone marrow cell　　　　　　　　 cell cycle　　　　　　　　　　apoptosis 骨髓抑制是肿瘤病人放、化疗的主要并发症之一，其所致白细胞减少诱发的感染和血小板减少引起的出血，严重影响病人的治疗和预后［1］。主要表现为神疲乏力、腰膝酸软、食欲减退、面色无华、心悸耳鸣等非特异性症状，属于中医的“虚劳”范畴 。近年来，有