β受体阻滞剂的降压地位解读.pptx

β受体阻滞剂的降压地位解读;报 告 提 纲;?-阻滞剂：心血管领域主要治疗药品;肾上腺髓质-----肾上腺素 交感神经末梢-----去甲肾上腺素;肾上腺素能受体亚型分布与效应;肾上腺素能受体亚型分布与效应;(Partial Agonist activity);?-受体阻滞剂可能降压机制;?-受体阻滞剂分类;?-受体阻滞剂药理学差异;?-阻滞剂亲脂性和长久心脏保护（一级预防试验）;?-阻滞剂亲脂性和长久心脏保护（二级预防试验）;心肌梗死后?-阻滞剂长久治疗;个别?-阻滞剂药理学特征; ?-阻滞剂降压疗效及地位  - MAPHY 和 STOP-H 研究  - BPLTTC 结果 - JNC-7 概览 ;?-受体阻滞剂：高血压治疗一线药品;倍他乐克降压一级预防试验（MAPHY）;MAPHY：总死亡率曲线;;瑞典老年高血压试验（STOP-H）;STOP-H：主要终点和死亡率;;Contributing trials;Newer blood pressure lowering agents versus placebo More intensive versus less intensive blood pressure lowering regimens Blood pressure lowering regimens based on different drug classes ;Primary outcomes Stroke Coronary heart disease Heart failure (fatal or hospitalised) Total cardiovascular events (composite of all above) Cardiovascular mortality Total mortality;STROKEComparisons of active treatments and control;STROKEComparisons of different active treatments;CORONARY HEART DISEASEComparisons of active treatments and control;CORONARY HEART DISEASEComparisons of different active treatments;HEART FAILUREComparisons of active treatments and control;HEART FAILUREComparisons of different active treatments;MAJOR CARDIOVASCULAR EVENTSComparisons of active treatments and control;MAJOR CARDIOVASCULAR EVENTS Comparisons of different active treatments;CARDIOVASCULAR DEATHComparisons of active treatments and control;CARDIOVASCULAR DEATHComparisons of different active treatments;TOTAL MORTALITYComparisons of active treatments and control;TOTAL MORTALITYComparisons of different active treatments; Similar net effects on total cardio- vascular events of: Diuretics/beta-blockers ACE inhibitors Calcium antagonists ARBs also effective in reducing total cardiovascular events ; ACE-inhibitor and diuretic/beta-blocker based regimens more effective than calcium antagonists for preventing heart failur