纤维支气管镜肺泡灌洗联合常规治疗慢性阻塞性肺疾病急性加重期的效果及对患者炎性指标的影响.docxVIP

纤维支气管镜肺泡灌洗联合常规治疗慢性阻塞性肺疾病急性加重期的效果及对患者炎性指标的影响 　　【摘要】目的：探讨纤维支气管镜肺泡灌洗联合常规治疗慢性阻塞性肺疾病急性加重期（aecopd）的效果及对患者炎性指标的影响。方法：收集2016年8月-2018年5月于笔者所在医院治疗的90例慢性阻塞性肺疾病急性加重期患者，按随机数字表法分为参照组和研究组，各45例。参照组患者予以常规治疗，研究组在参照组的基础上予以纤维支气管镜肺泡灌洗治疗。对比两组治疗后的临床总有效率、肺功能指标fev1和pef水平、炎性指标pct、crp和wbc水平。结果：研究组的近期总有效率优于参照组，差异有统计学意义（p0.05）;治疗前两组的肺功能指标fev1和pef水平及炎性指标pct、crp和wbc水平比较，差异均无统计学意义（p0.05）;治疗后研究组fev1和pef水平均高于参照组，差异均有统计学意义（p0.05）;治疗后研究组pct、crp及wbc水平均低于参照组，差异均有统计学意义（p0.05）。结论：纤维支气管镜肺泡灌洗联合常规治疗慢性阻塞性肺疾病急性加重期较单一常规诊治的疗效更高，可改善患者的肺功能及减少炎症反应。 　　【关键词】纤维支气管镜肺泡灌洗慢性阻塞肺疾病急性加重期 　　[abstract]objective：toinvestigatetheeffectofbronchoscopicalveolarlavagecombinedwithroutinetherapyonacuteexacerbationofchronicobstructivepulmonarydisease（copd）anditsinfluenceoninflammatorymarkers.method：atotalof90patientswithacuteexacerbationofchronicobstructivepulmonarydiseasetreatedinourhospitalfromaugust2016tomay2018wererandomlydividedintothereferencegroupandtheresearchgroup，45casesineachgroup.thecontrolgroupreceivedroutinetreatment，whilethestudygroupreceivedbronchoscopicalveolarlavageonthebasisofthecontrolgroup.theclinicaltotaleffectiverate，lungfunctionindexessuchasfev1andpeflevels，andinflammatorymakerssuchaspct，crpandwbclevelswerecomparedbetweenthetwogroupsaftertreatment.result：theshort-termtotaleffectiverateofthestudygroupwasbetterthanthatofthecontrolgroup，thedifferencewasstatisticallysignificant（p0.05）.therewerenosignificantdifferencesinthelevelsoffev1andpef，pct，crpandwbcinthetwogroupsbeforetreatment（p0.05）.aftertreatment，thelevelsoffev1andpefinthestudygroupwerehigherthanthoseinthecontrolgroup，thedifferenceswerestatisticallysignificant（p0.05）.aftertreatment，thelevelsofpct，crpandwbcinthestudygroupwerelowerthanthoseinthecontrolgroup，thedifferenceswerestatisticallysignificant（p0.05）.conclusion：fiberopticbronchoscopicalveolarlavagecombinedwithroutinetreatmentforacuteexacerbationofchronicobstructivepulmonarydiseaseismoreeffectivethansingleroutinetreatment，whichcanimprovepulmonaryfunctionandreduceinflammation. 　　 　　慢性阻塞