胃癌患者血清脂联素水平变化及其临床研究.docxVIP

胃癌患者血清脂联素水平变化及其临床研究 　　【摘要】目的：探讨血清脂联水平在胃癌患者中的临床应用价值。方法：选择经胃镜及组织活检和/或手术病理学确诊的胃癌患者120例[按照胃癌国际抗癌联盟（uicc）分期标准：ⅰ期60例，ⅱ期12例，ⅲa期23例，ⅲb期12例，ⅳ期13例]，良性胃疾病组100例，正常对照组110例，用酶联免疫法（elisa）法检测血清脂联素水平，分析血清脂联素水平在胃癌组、良性胃疾病组、健康对照组的水平，以及不同胃癌分期患者血清脂联素水平的差异。结果：胃癌组患者脂联素水平显著低于健康对照组及良性胃疾病组，差异均有统计学意义（p0.01）;胃癌ⅳ期血清脂联素水平低于ⅰ、ⅱ期及ⅲ期，ⅲ期血清脂联素水平低于ⅰ、ⅱ期，差异均有统计学意义（p0.01）。结论：胃癌患者血清中脂联素水平呈现低表达，且随着胃癌病情进展进行性降低，脂联素水平检测可作为早期胃癌筛查及预后判断指标之一。 　　【关键词】胃癌;良性胃疾病;脂联素;酶联免疫法 　　doi：10.14033/j.cnki.cfmr.2019.25.025文献标识码b文章编号1674-6805（2019）25-00-03 　　changesofserumadiponectinlevelsinpatientswithgastriccanceranditsclinicalstudy/changfan，jirongzu，sheguangting，etal.//chineseandforeignmedicalresearch，2019，17（25）：-62 　　【abstract】objective：toinvestigatethesignificanceofclinicalapplicationofserumadiponectinlevelsinpatientswithgastriccancer.method：atotalof120patientswithgastriccancerdiagnosedbygastroscopyandtissuebiopsyand/orsurgicalpathologywereselected.accordingtotheinternationalclassificationofgastriccancerinternationalunion（uicc）stagingcriteria：60casesinstageⅰ，12casesinstageⅱ，23casesinstageⅲa，12casesinstageⅲb，and13casesinstageⅳ.and100caseswereselectedasbenigngastricdiseasegroupand110casesinnormalsubjectsashealthycontrolgroup.serumadiponectinlevelsinallsubjectsweremeasuredbyenzyme-linkedimmunosorbentassay（elisa）.thedifferencesofserumadiponectinlevelsamongpatientswithgastriccancergroup，benigngastricdiseasesgroup，andhealthycontrolgroupwerefurtheranalyzed.result：theserumadiponectinlevelofgastriccancerpatientswassignificantlylowerthanthatofhealthycontrolgroupandbenigngastricdiseasegroup，thedifferenceswerestatisticallysignificant（p0.01）.thelevelofserumadiponectininstageⅳofgastriccancerwaslowerthanthatinstageⅰ，ⅱandstageⅲ，andthelevelinstageⅲofgastriccancerwaslowerthanthatinstageⅰ，ⅱ，thedifferenceswerestatisticallysignificant（p0.01）.conclusion：theserumadiponectinlevelisreducedingastriccancerpatients，anditdecreasesprogressivelywiththeprogressionofgastriccancer.detectionofadiponectinlevelcanbeusedasoneoftheearlygastricc