什么是生物数学.pptVIP

Theorem 4.1 Suppose that (H), hold and Eq.(14) has positive roots. and have the same meaning as last definition. We get (1) All root of Eq.(4) have negative real parts for and the equilibrium of system (2) is asymptotically stable for . (2) If hold , then system (2) undergos a Hopf bifurcation at the equilibrium E, when . 第三十页，共五十一页。 5.Stability and direction of the Hopf bifurcation In the previous section, we obtained conditions for Hopf bifurcation to occur when . In this section we study the direction of the Hopf bifurcation and the stability of the bifurcation periodic solutions when , using techniques from normal form and center manifold theory. 第三十一页，共五十一页。 We assume Letting and dropping the bars for simplification （17） 第三十二页，共五十一页。 Where and (18) Where 第三十三页，共五十一页。 第三十四页，共五十一页。 From the discussion in Section 2, we know that system (10) undergos a Hopf bifurcation at (0,0,0) when , and the associated characteristic equation of system (10) with has a pair of simple imaginary roots . 第三十五页，共五十一页。 Result Based on the above analysis, we can see that each gij can be determined by the parameters. Thus we compute the following quantities: 第三十六页，共五十一页。 HOPF BIFURCATION IN A SYNAPTICALLY COUPLED FHN NEURON MODEL WITH TWO DELAYS Liping Zhang College of Science, Nanjing University of Aeronautics and Astronautics 2010/07/30 第一页，共五十一页。 什么是生物数学？ 生物数学是生物学与数学之间的边缘学科，用数学方法研究和解决生物学问题，也对与生物学有关的数学方法进行理论研究。 对于今天的生物学者，数学的价值更应该体现在建立在数量化基础上的模型化。通过数学模型的构建，可以将看上去杂乱无章的实验数据整理成有序可循的数学问题，将问题的本质抽象出来。 第二页，共五十一页。 两个最近的事例 SARS 在对SARS的研究中，生物数学就发挥了作用。2003年春SARS暴发时，在有效的疫苗和抗病毒药物研制出来之前，科学家最关心的是SARS流行的特征。两个国际合作的研究小组使用了SEIR数学模型，对SARS的传播趋势进行分析和预测，给有关部门提供了参考意见。 第三页，共五十一页。 Avian Influenza Bird flu Avian influenza is a disease of birds caused by influenza viruses closely related to human influenza viruses