PROTAC-Axl-Degrader-1-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE PROTAC Axl Degrader 1 Cat. No.: HY-144624 分⼦式: C₄₀H₄₃N₁₁O₄ 分⼦量: 741.84 作⽤靶点: PROTACs; TAM Receptor 作⽤通路: PROTAC; Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 PROTAC Axl Degrader 1 是⼀种有效的选择性 PROTAC Axl 降解剂，IC50 为 0.92 µM。PROTAC Axl Degrader 1 显⽰出体外抗增殖活性、抗迁移活性。PROTAC Axl Degrader 1 诱导巨泡式细胞死亡 [1]。 IC50 Target IC50: 0.92 µM (AXL) [1] 体外研究 PROTAC Axl Degrader 1 (compound 22) (72 h) shows anti-proliferation activity with IC50s of 10.34 µM, 5.53 µM, for MDA-MB-231, 4T1 cells, respectively [1]. PROTAC Axl Degrader 1 (0.5, 2 µM; 24, 48 h) decreases the abundance of AXL in MDA-MB-231 cells [1]. PROTAC Axl Degrader 1 (1, 2 µM) reduces the expression of AXL, could be restored in the presence of EPO (epoxymycin) [1]. PROTAC Axl Degrader 1 (1, 10 µM; 48 h) significantly inhibits the migration in MDA-MB-231 and 4T1 cells [1]. PROTAC Axl Degrader 1 (0.5 µM) induces cytoplasmic vacuolation (methuosis) in MDA-MB-231 and 4T1 cells [1]. Cell Proliferation Assay [1]