甲状腺激素和抗甲状腺药Thyroidhormonesandantithyroiddrugs.pptxVIP

甲状腺激素和抗甲状腺药Thyroidhormonesandantithyroiddrugs第1页/共34页 甲状腺激素和抗甲状腺药Thyroid hormones and antithyroid drugs第2页/共34页 Thyroid hormones and antithyroid drugsSummaryThyroid hormones Necessary to maintain normal metabolism , growth and development.Hypothyroidism Cause Cretinism if it happens in embryo or neonatal period. Cause myxedema if it happens in adults when the thyroid hormone could be used in replacement therapy.Hyperthyroidism A syndrom characterized by thyroid oversecretion and metabolic disorder caused by multiple reasons. It can be treated with radioactive iodine (131I) irradation , antithyroid drugs and operation.第3页/共34页 Thyroid hormonesInclude：Thyroxine,T4Triiodothyreninum natricum，T3Synthesized and secreted by thyroid第4页/共34页 Antithyroid drugsFour categories： 硫脲类（Thiourea）碘和碘化物 （复方碘溶液,lugol’s solution）放射性碘（131I）β受体阻断药（心得安等从略）第5页/共34页 硫脲类（Thiourea）硫氧嘧啶类（thiouracil）：甲基硫氧嘧啶（methykthiouracil）丙基硫氧嘧啶（propylthiouracil）咪唑类（imidazoles）他巴唑 （Tapazole，甲巯咪唑methimazole）甲亢平（卡比马唑Carbimazole）第6页/共34页 ThyroidhormonesThyroid hormones are iodic amino acidsActive components Thyroxine,T4 Triiodothyreninum natricum，T3Chemical constitution第7页/共34页 Chemical constitution of thyriod hormones第8页/共34页 Thyroid hormonesphysiological dispositionAbsorbed rapidly when take orally , activity T3T4，maintaining time T4T3。T1/2 of T4 and T3 are 6－7 days and 1－2 days , respectively。Deiodination in mitochondria of liver and kidney , eliminated by kidney affer conjugated with glucuronic acid and sulfuric acid. T3、T4 can also pass the placenta and enter milk.Figure：the amount of normal adults’ thyroid hormones produced and metabolized daily.第9页/共34页 Synthesis , storage and regulation of thyroid hormonesIodine uptakeIodine activation and tyrosine iodationCondensation and storageDisintegration and releaseRegulation第10页/共34页 Steps of thyroid hormones synthesis , release and regulationIodine uptake：I－ in blood can be uptaken into cells by iodine pump in the ad