胰岛素抵抗糖尿病与冠心病.ppt

胰岛素抵抗糖尿病与冠心病第一页，共二十九页，2022年，8月28日 Adapted from World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva: World Health Organization:1999:52.Criteria for the Diagnosis of Diabetes Mellitus and HyperglycemiaPlasma Glucose Concentration7.0 (126) 6.1 (110) to 7.0 (126)2-Hour PostGlucose LoadFastingGlucoseDiabetes MellitusImpaired Glucose ToleranceImpaired Fasting Glucose11.1 (200)7.8 (140) to11.1 (200) Values are mmol/L (mg/dl)第二页，共二十九页，2022年，8月28日 DevelopedDevelopingPercentKing H et al. Diabetes Care 1998;21:1414-1431.World1995Prevalence of Diabetes in Adult Population(Aged 20 years) by Year and Regio三页，共二十九页，2022年，8月28日 Hospitalization Costs for Chronic Complications of Diabetes in the USAmerican Diabetes Association. Economic Consequences of Diabetes Mellitusin the US in 1997. Alexandria, VA: American Diabetes Association, 1998:1-14.Total costs 12 billion US $CVD accounts for 64% of total costsOthersOphthalmic diseaseCardiovasculardiseaseRenal diseaseNeurologic diseasePeripheral vascular disease第四页，共二十九页，2022年，8月28日 Annual CHD Deaths per 1000 PersonsKannel WB, McGee DL. JAMA 1979;241:2035-2038.Framingham Study: DM and CHD Mortality20-Year Follow-up178174MenWomenDMNon-DM第五页，共二十九页，2022年，8月28日 Ischemicheartdisease% of DeathsGeiss LS et al. In: Diabetes in America. 2nd ed. 1995; chap 11.Mortality in People with DiabetesCauses of DeathOtherheartdiseaseDiabetesCancerStrokeInfectionOther第六页，共二十九页，2022年，8月28日 Mortality per 1000 person-years**Age-adjustedAdapted from Gu K et al. Diabetes Care 1998;21:1138-1145.Mortality Due to Heart Disease in Men and Women with or without Diabetes (US)29.919.2MenWomenDiabetesNo DiabetesAll heart diseaseIschemic heart diseaseMenWomen11.56.323.07.111.03.6第七页，共二十九页，2022年，8月28日 NondiabetesDiabetes *Defined in 1971-1975, followed up through 1982-1984.**Defined in 1982-1984, followed up through 1992-1993.Gu K et al. JAMA 1999;281:1291-1297.Tr