神经退行性疾病干细胞移植治疗目前研究现状与未来展望.pptVIP

Stem Cell Sources for Treatment of Neurological Diseases (AD, PD, ALS, MS, Stroke, SCI)Fabin Han, et al, Journal of Neurorestoratology 2015:3 1–12当前第1页\共有35页\编于星期四\20点 胎儿神经干细胞治疗帕金森氏病临床研究发展历程Evans JR, Mason SL, Barker RA. Prog Brain Res. 2012;200:169-98 当前第2页\共有35页\编于星期四\20点 Lindvall O, et al，Nat Med. 2008 May;14(5):501-3THSynucleinOverlayTransplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons当前第3页\共有35页\编于星期四\20点 Synuclein-HostUbiquintin-HostSynuclein-Grafted NeuronsUbiquintin-Grafted NeuronsGrafted nigral neurons were found to have Lewy body-like inclusions14 years after transplantation into the striatum of an individual with PDOlanow CW. et al Nat Med. 2008May;14(5):504-6.当前第4页\共有35页\编于星期四\20点 Transplanted dopamine neurons in people with PD do not contain Lewy bodiesMendez, Isacson et al, , NATURE MEDICINE VOLUME 14 (5):507-509, 2008当前第5页\共有35页\编于星期四\20点 Freed CR, J Nucl Med. 2010 Jan;51(1):7-15 - Long term Study- 33 of the original trial participants who were followed for 2 years after transplantation and 15 of these subjects who were followed for 2 additional years. - These results suggest that clinical benefit and graft viability are sustained up to 4 y after transplantation. Freed CR, Neurotherapeutics (2011) 8:549 –561当前第6页\共有35页\编于星期四\20点 人体胚胎干细胞分化的多巴胺神经元移植改善小鼠，大鼠和猴子帕金森氏病的运动障碍22/29 DECEMBER 2011 | VOL 480 | NATURE | 547，Lorenz Studer，et al Memorial Sloan-Kettering Cancer Center当前第7页\共有35页\编于星期四\20点 Improved Cell Therapy Protocol for Parkinson’s Disease Based on Differentiation Efficiency and Safety of hESC-, Hipsc and Non-Human Primate iPSC-Derived DA NeuronsIsacson et al, , Stem Cells. 2013 ;31(8):1548-62.当前第8页\共有35页\编于星期四\20点 Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo.  Zhou z, et al, Proc Natl Acad Sci U S A.2014 Nov 4;111(44):15804-9当前第9页\共有35页\编于星期四\20点 iPSC-Derived Dopamine Neurons function after Transplantation in a No