利拉鲁肽对初发2型糖尿病伴肥胖患者疗效及微炎症状态的影响研究.docVIP

·3339 · · 论 著 · 利拉鲁肽对初发2型糖尿病伴肥胖患者疗效及微炎症状态的 影响研究 奚 悦 【摘要】 目的 探讨利拉鲁肽对初发2型糖尿病伴肥胖患者临床疗效及微炎症状态的影响。方法 将60例初发 2型糖尿病伴肥胖患者随机分为生活方式干预组(20例)、二甲双胍治疗组(20例)及利拉鲁肽治疗组(20例),疗 程为16周。观察治疗前后3组患者空腹血糖 (FBG)、 糖化血红蛋白 (HbA?。)、体质指数 (BMI)、 急性时相血清淀粉 样蛋白A(ASAA)、 白介素6 (IL-6)、 肿瘤坏死因子α (TNF- α) 等指标水平的变化。结果 治疗前3组患者BMI、 FBG、HbA,。、ASAA、IL-6、TNF- α 水平间差异均无统计学意义 (P0.05); 而治疗后3组各指标间差异均有统计 学意义 (P0.05), 其中利拉鲁肽治疗组各指标水平均低于生活方式干预组和二甲双胍治疗组，差异有统计学意义 (P0.05)。 结论 利拉鲁肽对初发2型糖尿病伴肥胖患者的血糖和体质量的控制明显优于二甲双胍治疗和单纯生活 方式干预，并且能明显改善患者的微炎症状态。 【关键词】 糖尿病，2型；肥胖；利拉鲁肽；急性时相血清淀粉样蛋白A; 白细胞介素6;肿瘤坏死因子α 【中图分类号】 R587.1 【文献标识码】 A doi:10.3969/j.issn.1007-9572.2013.10.017 奚悦，利拉鲁肽对初发2型糖尿病伴肥胖患者疗效及微炎症状态的影响研究 [J]. 中国全科医学，2013,16 (10):3339-3340.[] Effect of Liraglutide in Patients with Type 2 Diabetes and Obesity and on Their Micro-inflammation XI Yue. Department of Endocrinology, the Third Affliated Hospital of Liaoning Medical University,Jinzhou 121000,China 【Abstract】 Objective To investigate the clinical effect of liraglutide in patients with type 2 diabetes and obesity and on their micro - inflammation. Methods Totally 60 cases newly diagnosed with type 2 diabetes were randomly divided into three groups; lifestyle intervention group (n=20),metformin treatment group(n =20), and liraglutide treatment group (n=20). All groups were treated for 16 weeks. The levels of fasting blood glucose(FBG),HbA,o,body mass index(BMI),acute - phase serum amyloid A(ASAA), interleukin 6(IL-6), and tumor necrosis factor α(TNF -α)of the three groups were measured before and after the treatment. Results No significant difference was observed among the three groups before the treat- ment in all abovementioned indices. After treatment, the levels of FBG, HbA,, BMI,ASAA,IL-6,and TNF-α in the lira- glutide treatment group were significantly lower than those in the lifestyle intervention group and the metformin treatment group (P 0.05). Conclusion Liraglutide is more effective in controlling blood glucose and body weight than the metformin treatment and li