片剂的制备工业药剂.pptVIP

当前第1页\共有37页\编于星期一\7点 Purpose Introduction Equipments and Materials Procedures Experimental Instructions Questions Test report 当前第2页\共有37页\编于星期一\7点 Purpose 1. To master the basic technological course of tablets through the preparation of aspirin tablets. 2. To be familiar with the quality control of tablets. 3. To be familiar with the basic structure and operation method of single-punch. 当前第3页\共有37页\编于星期一\7点 Introduction Tablets are solid preparations of various shapes, usually round, and obtained by compressing uniform volumes of particles containing one or more active ingredients with suitable excipients. 当前第4页\共有37页\编于星期一\7点 Introduction -- tablet types Some of the pharmaceutical tablet types based on the way of administration or presentation to the patient are listed on the right: 1. Simple uncoated tablets 2. Coated tablets 3. Effervescent tablets 4. Buccal and sublingual tablets 5. Chewable tablets 6. Multilayered tablets 7. Sugarcoated tablets 8. Fast-disintegrating tablets 9. Vaginal tablets 10. Osmotic tablets 11. Controlled-release tablets 12. Multicomponent tablets 当前第5页\共有37页\编于星期一\7点 Introduction -- tablet design Tablet formulation design starts with a predetermined value, which is the dose size. Tablet design is based on the experience and knowledge of excipients, which are materials serving the purpose of making a good tablet when combined with a drug. 当前第6页\共有37页\编于星期一\7点 Introduction -- tablet design Tablet excipients can be classified on the basis of their functionality as listed below: 1. Fillers/diluents 2. Binders 3. Disintegrants 4. Lubricants 5. Glidants 6. Buffering agents 7. Sweeteners 8. Wetting agents 9. Coating agents 10. Matrix formers 当前第7页\共有37页\编于星期一\7点 Introduction -- manufacturing processes Deciding on a manufacturing method is a complex task that requires time, equipment, and formulation optimization, as well as a close collaboration between formulation scientists and process engineers. In general terms, there are three manuf