药理学教学课件：Chapter 20 Antipyretic-analgesic and Anti-inflammatory Drugs.pptVIP

1 Chapter 20 Antipyretic-analgesic and Anti-inflammatory Drugs ( Non-Steroidal Anti-Inflammatory Drugs, NSAIDs ) These drugs relieve the pain associated with inflammation, including that from arthritis and gout.They produce their anti-inflammatory action through a different mechanism, not as glucocorticoid.Classed into non-steroidal anti-inflammatory drugs (NSAIDs) in 1974.2 3 Introduction Non-Steroidal Anti-Inflammatory Drugs, NSAIDsA Antipyretic （一）PG Synthetase （Cyclooxygenase）in the hypothalamic thermoregulatory center Characteristics： Making cooling of body temprature of feverB Analgesic（一） PG Synthetase （Cyclooxygenase）in the peripheral pain positionC Anti-Inflammatory （一） PG Synthetase （Cyclooxygenase）in the peripheral inflammatory position 4Antipyretic ActionFebrile: Endogenous pyrogen →CNS→Release PG↑ → Thermoregulatory center → FebrileAntipyretic: Inhibit PG synthetase，Decrease synthesis of PG →Hypothermy 5 depress bradykinin pain sensorantipyretic analgesic pain stimulus PG synthesis sensitization depress Mechanisms: Inhibit the synthesis of prostaglandins and prevent bradykinin from stimulating pain receptors, also inhibit the recognition of pain impulses peripherally.Analgesic Action 6Anti-Inflammatory ActionMechanisms: Inhibit a primary pathway in PG synthesis. Summary: By inhibiting the PG synthesis to show antipyretic, analgesic and anti-inflammatory effects. 7 8NSAIDs show different effects to COX-1 and COX-2：The stronger the inhibiting effects to COX-1，the more adverse reaction the drug has； The stronger the inhibiting effects to COX-2， the more obvious the antipyretic-analgesic and anti-inflammatory effects the drug has. 9Non Selectively Cyclooxygenase Inhibiting Drugs A Salicylic Acid B Aniline C Indole D Aryl Acetic Aci