药剂学课件：第一章 概述.pptVIP

Biopharmaceutics (Biopharmacy) Chapter 1Introduction  Branches of pharmaceutics Physical pharmaceuticsIndustry pharmaceuticsBiopharmaceuticsClinical pharmaceutics I. Concept Study on the process of absorption, distribution, metabolism and excretion of drug and its dosage form in vivo. to state a relationship between the factor of biology and dosage form and the pharmacologic effect of drugto provide scientific basis for evaluation of quality of the drug preparation and design and use of drug products rationally 1. Factors of dosage form Type of drugPhysical and chemical properties of drugDosage form and administration of drug The nature of excipients and additives and the dose of drugThe technological process and operation conditions of preparation Incompatibility and interaction between drugs Type of drugi.e. ester, salt, complex, derivative and so one.g. The solubility of sodium tolbutamide (甲磺丁脲钠)is better than that of tolbutamide. The pharmacologic effect is either. Physical and chemical properties  of drug i.e. diameter of particle, crystal form, solubility, dissolution rate and so onDissolution is the process by which a chemical or drug becomes dissolved in a solvent Lots of facts have proved that the dissolution rate of tablets influences the absorption and clinical therapeutic effect.At the present, the pharmacopeia of China and many other countries all have requirement of dissolution rate for solid preparations such as tablets or capsules. e.g. convention tabletsmicronized tabletssolid dispersion(pills)Griseofulvin (灰黄霉素) Dosage form and administration  of drug  i.e. tablets, capsules, injections, transdermal therapeutic system (TTS) and so on. e.g. the therapeutic effect of injections is faster than that of tablets. Because the former was absorbed rapidly to the blood syst