内科学课件： 胃炎（英文版）-.pptVIP

Gastritis

InjuryofgastricmucosaInjuryofEpitheliumMucosalinflammationRegenerationofepithelialcellGastritis:acutegastritis、chronicgastritisGastropathyGastritis

Acutegastritis

Acutegastritis

?Acutestress?AcuteerosionhemorrhagicgastritisChemicalinjury?Acutecorrosivegastritis?NSAID-relatedgastritis?Acutebacterialinfection?Acutepurulentgastritis

ArachidonicacidCOXCOX-1COX-2(Architectonicenzyme）（Inducedenzyme）PGProtectandregulategastrointestinalcells、kidney、bloodvesselCauseinflammationandacheChargebasicPGcompositionChargepathologicalPGcompositionNSAIDs__COX-2inhibitors_

NSAIDs--“antwo-bladeknife”FirstuseddrugsforboneandarticularmuscleacheAnti-inflammationandalleviatepainThirty?millionpatientsuseeverydayintheworld,theoldersaccounts40%Inthecourseofuse，especiallylong-timeandhigh-doseusage,itcanalwayscausesInjuryofGIInUK,theside-effectcausedbyNSAIDsaccounts25%ofalldrugs

HighriskpatientsfortoxicactionofGItractRiskfactorsEvidencesHigh-age（70yers）+++Historyofpepticulcer+++Hpinfection+/-CombinedmedicationOtherNSAIDsorAspirin++Steroid+Decoagulant+Smoking+Drinking+

SeriousburnCurlingulcerSeriousCNSchangesCushingulcerMucosalmicrocirculationdisturbance!Acid,pepsineHowdoesstressleadstomucosadamage?

Clinicalmanifestation

Symptoms?primarydiseasemanifestation：shock、burn、trauma……?upperGIsymptoms:upperabdominalpain、nausea、vomiting……?upperGIhemorrhage：hematemesis、melena?Signs

ElectronicgastroscopeX-raycheckChangepositionSwallowbarium

TreatmentofacutegastritisEliminateetiopathogenisisInhibitgastricacidProtectgastricmucosaHemorrhagetherapySwallowNESymptomatictreatment

chronicgastritis

chronicgastritisChronic、non-specificgastricmucosalinflammationcausedbyvariousetiopathogenisis?chieflybyHpinfectionClassification?changes：supe