NPFF2-R-ligand-1-DataSheet-生命科学试剂-MCE.pdf

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NPFF2-Rligand1

Cat.No.:HY-161382

分⼦式:C₃₂H₄₁N₃O

分⼦量:483.69

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NPFF2-Rligand1(Compound16a)是⼀种NPFF2-R配体，对NPFF1-R和NPFF2-R的Ki值分别为228和27

nM。NPFF2-Rligand1可⽤于中枢神经系统相关疾病的研究。

体外研究NPFF2-Rligand1showslowbindingaffinitytoDOR,KORandMOR,withKivaluesof10000,913,2180

nMrespectively[1].

REFERENCES

[1].GalalKA,etal.Guanidine-to-piperidineswitchaffordshighaffinitysmallmoleculeNPFFligandswithpreferenceforNPFF1-Rand

NPFF2-Rsubtypes.EurJMedChem.2024Mar23;269:116330.

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