NY0116-DataSheet-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

NY0116

Cat.No.:HY-124681

CASNo.:1003000-59-6

分⼦式:C₂₂H₂₃N₃O

分⼦量:345.44

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NY0116是⼀种神经调节肽U受体2(NMUR2)激动剂，hNMUR1的EC50值为27.76μM，hNMUR2的EC50

值为13.61μM。NY0116降低cAMP，同时刺激稳定表达NMUR2HEK293细胞中的钙信号传导。

体外研究NY0116haspotentdose-dependentinhibitionofcAMP(EC50of1.69nM)inHEK293cellsstablyexpressing

hNMUR2.NY0116alsostimulatescalciumsignalingincells[1].

体内研究NY0116(3-30mg/kg;SC;;for14days)decreasesbodyweight,visceraladiposetissue,andcholesterolona

high‐fatdiet[1].

AnimalModel:Maledietinducedobese(DIO)C57BL/6Jmiceage18weeksand8age[1]

Dosage:3,10,30mg/kg

Administration:Subcutaneousinjection;for14days

Result:Significantlydecreasedbodyweightcomparedt