骨质疏松的诊断与治疗 (2).pptVIP

**Valuesarethenumberofpatientswhodiscontinuedthetreatment;thecorrespondingpercentageisgiveninparenthesis**Valuesarethenumberofpatientswhodiscontinuedthetreatment;thecorrespondingpercentageisgiveninparenthesis**Valuesarethenumberofpatientswhodiscontinuedthetreatment;thecorrespondingpercentageisgiveninparenthesis****Valuesarethenumberofpatientswhodiscontinuedthetreatment;thecorrespondingpercentageisgiveninparenthesis**细胞学角度，双膦酸盐被破骨细胞摄取，并主要聚集与细胞中，通过减少细胞皱褶，抑制其活性。分子生物学角度，它阻断焦膦酸法尼醇合酶的焦膦酸镁结合位点，抑制焦膦酸法尼醇合酶的活性，减少异戊二烯酯类形成，影响细