分子医学-炎症、感染与相关疾病.pptVIP

MyD88knockoutmicehavenoresponsetoLPSMyD88isessentialtoallinflammatorysignalingpathwaysMyD88s,asplicevariantofMyD88downregulatestheinflammatoryresponseMyD88interactswithTIRdomainofTLRandrecruitsIRAK-4,IRAK-1andTRAF-6MyD88AdaptorRakoff-Nahoumetal.,RecognitionofcommensalmicroflorabyToll-likereceptorsisrequiredforintestinalhomestasis.Cell118:229-41,2004.*4IRAKsknown,IRAK1,IRAK-2,IRAK-MandIRAK-4IRAKareserine/threoninekinasesIRAK-4phosphorylatesIRAK-1IRAK-MplaysaninhibitoryroleinTLRsignalingTRAF6isamembero