EB病毒所致相关疾病肝损害的研究进展.doc

EB病毒所致相关疾病肝损害的研究进展

摘要：EB病毒感染引起的相关疾病，对儿童的生命健康造成了很大的威胁，其所致的肝损害是指临床上以血清学证实为原发性急性EB病毒感染或活动性感染，并除外其他病原感染所致的肝损害。EB病毒相关性传染性单核细胞增多症与慢性活动性EB病毒感染可表现为持续性肝功能损害，而EB病毒相关的嗜血细胞综合征、X连锁淋巴组织增生性疾病等可以出现凝血功能异常、暴发性肝炎、肝衰竭等。EB病毒所致肝损害是EB病毒感染之后的细胞因子和淋巴细胞浸润导致的免疫性损伤。患病后，症状轻者，可以经对症支持治疗自然缓解，如果有明显肝损害者应卧床休息，使用抗病毒药物等支持治疗。慢性活动性的EB病毒感染和EB病毒相关的嗜血细胞综合征出现肝损害时则主要是针对于原发的疾病进行相应治疗，除了常规对症支持治疗外，需进行骨髓移植和化疗，而此时的阿昔洛韦等相关的抗EB病毒治疗是无效的。通过探讨EB病毒引起相关疾病的肝功能损伤分析，从而为临床的诊治提供更为有效的依据和参考。

关键词：EB病毒肝损害儿童

ResearchProgressofliverdamageinrelatedDiseasescausedbyEBvirus

Abstract：TherelateddiseasescausedbyEBvirusinfectionposeagreatthreattothelifeandhealthofchildren.TheliverdamagecausedbyEBVvirusinfectionreferstotheprimaryacuteEBVinfectionoractiveinfectionconfirmedbyserology.Withtheexceptionofliverdamagecausedbyotherpathogenicinfections.Epstein-BarrvirusassociatedinfectiousmononucleosisandchronicactiveEBvirusinfectioncanshowpersistentliverfunctiondamage,whileEBvirusassociatedhemophiliasyndrome,X-linkedlymphoplasticdiseasescanhaveabnormalcoagulationfunction,fulminanthepatitis,liverfailureandsoon.Epstein-BarrvirusinducedliverdamageisthecellularcauseofEBvirusinfection.Immuneinjurycausedbytheinfiltrationofchildrenandlymphocytes.Afterillness,thepatientswithmildsymptomscanberelievednaturallybysymptomaticsupporttherapy.Ifthereisobviousliverdamage,peoplewithobviousliverdamageshouldstayinbedanduseantiviraldrugstosupportthetreatment.WhenchronicactiveEBvirusinfectionandEBvirusrelatedhemophiliasyndromeoccurliverdamage,itismainlyfortheprimarydiseasestobetreatedaccordingly.Inadditiontoroutinesymptomaticsupporttreatment,bonemarrowtransplantationandchemotherapyareneeded.Atthistime,acyclovirandotherrelatedanti-EBvirustherapyisineffective.ToanalyzetheliverfunctiondamageofrelateddiseasescausedbyEBvirus,soastobeusedfo