糖尿病血管疾病并发症.pptVIP

AGEs形成过程AGEs参与糖尿病血管损伤的证据2型糖尿病肾病肾动脉切片，免疫组化显示肾动脉壁中有AGEs沉积（棕色）EricJ.Topol,etal.ReceptorforAGE(RAGE)MediatesNeointimalFormationinResponsetoArterialInjury.Circulation.2003;107(17):2238-2243A片正常鼠颈动脉切片；内膜及中层无明显AGEs沉积（免疫组化）B片为糖尿病鼠颈动脉切片；内膜及中层有明显AGEs沉积（褐色）AB胰岛素抵抗患者，糖化血红蛋白与左室重量、主动脉硬化相关。DimitriosAStakos,DaraPSchuster1,ElizabethASparks2,etal.Associationbetweenglycosylatedhemoglobin,leftventricularmassandaorticfunctioninnondiabeticindividualswithinsulinresistanceEuropeanJournalofEndocr