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CAPITALfurthersupportroutinePCIafterlysisfurthermeta-analysis:
newevidenceofPCIreasonableafterlysis溶栓后立即或缺血驱动PCI荟萃WijeysunderaH:AmHeartJ2008;156:564-572介入的发展:支架、IIb/IIIa溶栓药的发展:短效溶栓药介入的时机选对了为什么又行了?溶栓失败后的RescuePCI---不得不行到可行的过程RescuePCI—earlyRescuePCI(GUSTO-1)GUSTO-1---不补救更好KeytrialforrescuePCIMetaanalysisofRescuePCI2007易化PCI---与溶栓后PCI有区别01区别在哪里?02PACTPACTCAPTIMTrialarousesomehope
840ptsin27tertiarycareFrenchhospitalswithmobilecareunits2mmSTE-MI-ASA+Heparin5000U;pre-hospitaltPAvsprimaryPCIp=0.29p=0.61p=0.13p=0.12p=0.0630deventsrateBonnefoy,Lancet2002;360:825-29KeytrialsforfacilitatePCI如果已经准备PCI,不要乱给药了,不给更好FINESSEPCI前常规abciximab或PCI时嘱情abciximab的比较不管是否有半量瑞替普酶溶栓结果一样且院前应用Ab出血增多Finesse+OnTime2:PCI前Ab无益处01030204MetaanalysisforF-PCI
prePCITIMIflownottransfertogoodoutcomeMetaanalysisforF-PCIFacilitatePCI2007guidelinePharmacoinvasive概念的提出转运是安全的易化,立即,转运的综合问题:那些无法在90min内PCI的患者接受半量瑞替普酶+Ab后,是该立即转运作PCI还是等到发现未再通再进行转运补救PCI?180min110minD2BTheguidelinesdiscussindetailthedecisiontotakethetimefromfirstmedicalcontactorfirstdoortoballoonnumberto90minutes.ForthelastdecadetheimportanceoftimetotreatmentinPPCIhasbeendebated.Thenextfewstudiessupporttheargument“timedoesmatterinPPCI”.*“ThemortalitybenefitassociatedwithprimarypercutaneouscoronaryinterventioninST-segmentelevationmyocardialinfarctionmaybelostifdoor-to-balloontimeisdelayedby1hourascomparedwithfibrinolytictherapydoor-to-needletime.Interventionalcardiologylaboratoriesendeavoringtoachievethebenefitsofprimarypercutaneouscoronaryinterventionseeninrandomizedclinicaltrialsshouldaimtomatchtheirshortdoor-to-balloontimes”.(pg.824)Legendkey(pg.825)Absoluteriskreductionin4-to6-weekmortalityrateswithprimaryPCIasafunctionofPCI-relatedtimedelay.Circlesizesreflectthesampl
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