苏沈九宝汤对支气管哮喘急性发作患者Th1_Th2因子的影响.docx

苏沈九宝汤对支气管哮喘急性发作患者Th1/Th2因子的影响

张毅平廖小方诸葛建成楼炳恒

[中图分类号]?R256.12??????[文献标识码]?A??????[DOI]?10.3969/j.issn.1673-9701.2024.01.017

Effects?of?Sushen?Jiubao?decoction?on?Th1/Th2?factors?in?patients?with?acute?exacerbation?of?bronchial?asthma

ZHANG?Yiping1，?LIAO?Xiaofang1，?ZHUGE?Jiancheng1，?LOU?Bingheng2

1.Intensive?Care?Unit，?Sishengbianji?Hospital?of?Traditional?Chinese?Medicine?Affiliated?to?Zhejiang?Chinese?Medical?University，?Quzhou?324002，?Zhejiang，?China;?2.Department?of?Emergency，?Quzhou?Emergency?Command?Center，?Quzhou?324000，?Zhejiang，?China

[Abstract]?Objective?To?observe?the?clinical?efficacy?of?Sushen?Jiubao?decoction?in?the?treatment?of?acute?exacerbation?of?bronchial?asthma?and?its?effect?on?Th1/Th2?factors.?Methods?Ninety-eight?patients?with?acute?exacerbation?of?bronchial?asthma?treated?in?Sishengbianji?Hospital?of?Traditional?Chinese?Medicine?Affiliated?to?Zhejiang?Chinese?Medical?University?from?February?2022?to?May?2023?were?selected?and?divided?into?treatment?group?and?control?group?according?to?random?number?table?method，?with?49?cases?in?each?group.?The?control?group?was?given?conventional?treatment?such?as?oxygen?inhalation?and?atomization，?and?the?treatment?group?was?additionally?treated?with?Sushen?Jiubao?decoctionon?based?on?the?treatment?of?control?group.?The?clinical?efficacy，?TCM?syndrome?score，?pulmonary?function?indicators?[forced?expiratory?volume?in?first?second?（FEV1），?peak?expiratory?flow?（PEF）]，?and?laboratory?indicators?[interleukin?（IL）-4，?IL-13，?interferon-γ?（IFN-γ），?immunoglobulin?E?（IgE）].?Results?The?total?effective?rate?of?treatment?group?was?significantly?higher?than?that?of?control?group?（χ2=9.287，?P=0.010）.?After?treatment，?the?TCM?syndrome?scores，?serum?IL-4，?IL-13?and?IgE?levels?of?two?groups?were?significantly?lower?than?before?treatment，?and?FEV1，?PEF?and?IFN-γ?were?significantly?higher?than?before?treatment?（P0.05）.?The?TCM?syndrome?score，?serum?IL-4，?IL-13?and?IgE?levels?in?treatment?group?were?significantly?lower?than?t