家族性腺瘤性息肉病的临床特征分析.docx

家族性腺瘤性息肉病的临床特征分析

黄艳齐陈柯豫张玲利

[关键词]?家族性腺瘤性息肉病；临床特征；病理类型；癌变；治疗方式

[中图分类号]?R57????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.02.002

Clinical?characteristics?of?familial?adenomatous?polyposis

HUANG?Yanqi，?CHEN?Keyu，?ZHANG?Lingli

Department?of?Gastroenterology，?the?First?Affiliated?Hospital?of?Zhengzhou?University，?Zhengzhou?450052，?Henan，?China

[Abstract]?Objective?To?investigate?the?clinical?manifestations?of?familial?adenomatous?polyposis?（FAP）.?Methods?The?clinical?data?of?100?patients?with?FAP?diagnosed?in?the?First?Affiliated?Hospital?of?Zhengzhou?University?from?2011?to?2021?were?analyzed?retrospectively.?Results?The?main?clinical?manifestations?were?bloody?stool?（44.0%），?abdominal?pain?（40.0%），?changes?of?stool?characteristics?（25.0%），?abdominal?distension?（18.0%）?and?diarrhea?（17.0%）;?The?most?common?types?of?adenomas?were?villous?tubular?adenoma?（44.9%）?and?tubular?adenoma?（32.1%）;?Extraintestinal?manifestations：?3?cases?of?desmoid?fibroma，?2?cases?of?osteoma?and?1?case?of?lipoma.?47?cases?of?gastric?polyps?and?the?mostly?pathological?type?was?fundic?gland?polyp?（34.0%）.?18?cases?of?duodenal?polyps?including?6?cases?of?adenomatous?polyps?and?most?were?located?at?descending?duodenum?（61.1%）.?Adenoma?canceration?occurred?in?21?patients.?The?average?age?was?38.7?and?the?canceration?mainly?occurs?in?the?rectum.?The?gender，?family?history，?age?of?onset，?number?of?adenomas，?diameter?and?pathological?type?of?adenomas?were?statistically?compared?between?patients?with?and?without?canceration.?It?was?found?that?there?were?significant?differences?in?gender，?average?age?of?onset，?number?of?adenoma?polyps，?diameter?of?adenoma?and?pathological?type?between?the?two?groups?（P0.05）.?Conclusions?FAP?is?mainly?characterized?by?bloody?stool?and?abdominal?pain，?with?high?canceration?rate.?The?risk?factors?include?the?age?of?onset，?the?number?and?size?of?adenomas?and?the?pathological?type.?The?main?pathological?types?are?villous?tubular?adenoma?and?tubular?adenoma.?At?present，