肥胖、糖尿病、肿瘤复杂关系及临床启示.docxVIP

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糖尿病D|iabetes

学术前沿|Update

Diabetes

DiabetesUpdate

学术前沿

糖尿病、肥胖症和癌症病理生理学和临床意义

UYNH

Communication

Endocrinereviews

糖尿病、肥胖症和癌症病理生理学和临床意义

1肥胖，糖尿病与癌症风险复杂关系

2糖尿病治疗药物与癌症风险

3反向关联：癌症后糖尿病

4方法学分析和临床启示

糖尿病、肥胖症和癌症病理生理学和临床意义

1肥胖，糖尿病与癌症风险复杂关系

2糖尿病治疗药物与癌症风险

3反向关联：癌症后糖尿病

4方法学分析和临床启示

糖尿病被认为是结直肠癌、胰

糖尿病被认为是结直肠癌、胰腺癌、肝癌、胆囊癌、乳腺癌

及子宫内膜癌的高危因素

NoofEvidence

AssociationofdiabeteswithcasesP2forbias

Randomeffects(95%CI)

and95%predictionintervals

Random95%

effects(95%Cl)prediction

intervals

Prostatecancerincidence13597095No

0.91(0.82to1.01)0.49to1.69

Lungcancerincidence20745495No

1.03(0.94to1.13)0.7001.52

Gastriccancerincidence1597081Yes

1.09(0.98to1.22)0.7201.65

Totalcancerincidence3801079No

1.10(1.04to1.17)0.90to1.35

Kidneycancermortality26460Yes

1.16(1.01to1.33)0.97to1.37

Thyroidcancerincidence12300No

1.16(0.97to1.39)0.93to1.45

Totalcancermortality1138682No

1.16(1.04to1.30)0.80to1.70

Ovariancancerincidence765141Yes

1.17(1.02to1.34)0.79to1.72

Breastcancerincidence3085948No

1.20(1.12to1.28)1.01to1.43

Colorectalcancermortality439481No

1.20(1.03to1.40)0.74to1.94

Endometrialcancermortality10364Yes

1.23(0.78to1.93)0.28to5.36

Breastcancermortality444281Yes

1.24(0.95to1.62)0.49to3.16

Colorectalcancerincidence6169048No

1.27(1.21to1.34)1.07to1.52

Multiplemyelomaincidence305185Yes

1.27(0.98to1.64)0.56to2.86

Non-Hodgkinslymphomaincidence1235385Yes

1.27(1.09to1.48)0.70to2.30

Leukemiaincidence415689No

1.28(1.05to1.57)0.66to2.48

Gastriccancermortality244782Yes

1.29(1.04