爱吃糖的秘密——探索脑肠轴参与调节糖的偏好性的机制.docxVIP

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Diabetes

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—一探索脑肠轴参与调节糖的偏好性的机制

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糖的摄入多少会直接影响体重

正常饮食vs.高糖饮食

StudyMeanStandard

ifferenceerrorStudies(8weeks

Aeberil2011?7-0.170.13

Brynes2003?0.410.30

Marckmann2000320.900.43

Reid200780.300.70

Reid20100.360.22

Szanto19690.400.19Tordof1990?0.910.22Werner1984451.400.40Subtotal(95%C0

Testforheterogeneity:t2-0.20,

x2=30.39,df-7,PCO.001,P2-77%

Testforoveralleffect:z=2.70,P=0.007

Studies8weeks

3.972.601.750.57Poppitt20023?Raben

3.97

2.60

1.75

0.57

Subtotal(95%C0

Testforheterogeneity:t2=0.00,z2=0.56,df-1,P=0.46,2=0%

Testforoveralleffect:z=5.07,Pc0.001

Total(95%C1)

Testforheterogeneity:t2=0.35,

z2-50.93,df-9,PO.001,P2=82%

Testforoveralleffect:z=3.30,P=0.001Testforsubgroupdifferences:

Meandifference(95%CI)WeightMeandifference

Meandifference

(95%CI)

14.1-0.17(-0.42to0.08)

11.70.41(-0.18to1.00)

9.60.90(0.06to1.74)

6.10.30(1.07to1.67)

12.90.36(-0.07to0.79)

13.40.40(0.03to0.77)

12.90.91(0.47to1.35)

10.11.40(0.62to2.18)

90.80.52(0.14to0.89)

1.53.97(0.55t07.39)

7.72.60(1.49to3.71)

9.22.73(1.68to3.78)

100.00.75(0.30t01.19)

Highersugars

x2-14.98,df-1,Pc0.001,P-93.3%

少糖饮食vs.正常/高糖饮食

StudyMeanStandard

differenceerror

MeandifferenceWeightMeandifference

(95%CI)(%)(95%CI)

22.50.75(-0.02to1.52)

23.31.30(0.55to2.05)

38.40.40(-0.13to0.93)

13.00.90(-0.16to1.96)

2.81.99(-0.42to4.40)

100.00.80(0.39to1.21)4

Gatenby199728MannPaineau2008Saris20003?

Smith199641Total(95%Cl)

0.751.300.400.90

1.99

0.390.380.27

0.541.23

Testforheterogeneity:t2=0.04,x2=4.85,df=4,P=0.30,2=17%

LowersugarsHighersugars

Testforoveralleffect:z=3.85,P0.001

一项对RCT和队列研究进行的meta分析，一共纳入30个RCT和34个队列研究。其中分析了饮食含糖量与体重改变的关系。

TeMo