肠道病毒有哪些.pptVIP

Enteroviruses;问题;GroupsandSerotypes;EnterovirusesSerotypes;Surfacecleft–attachmenttocellularreceptors:

Immunoglobulinsuperfamily,integrins,ICAM-1;肠道病毒的特点;中和试验可分3个血清型,3型间有部分共同抗原

核酸有36-52%同源性

人类是唯一的易感宿主

在猴肾、人胚肾等细胞可增殖,表现为细胞变圆、坏死、脱落等典型溶细胞CPE

在猴、猩猩等灵长类动物敏感,在神经系统感染,导致肢体麻痹

;Transmission;Victimsofparalyticpolio;Childwithpoliosequelae?;ClinicalManifestations;免疫性;LaboratoryDiagnosis;预防原则;MostcountriesuseOPVbecauseofitsabilitytoinducelocalimmunityandalsoitismuchcheapertoproducethanIPV

ThenormalresponseratetoOPViscloseto100%.

OPVisusedfortheWHOpolioviruseradicationcampaign

Becauseoftheslightriskofparalyticpoliomyelitis,someScandinaviancountrieshaverevertedtousingIPV.Becauseofthelackoflocalimmunity,smallcommunityoutbreaksofpoliovirusinfectionshavebeenreported

;CurrentStatusofWildPoliovirusTransmission;我国政府规定每年12月5日和1月5日为脊灰疫苗日。;Coxsackievirusesaredistinguishedfromotherenterovirusesbytheirpathogenicityforsucklingratherthanadultmice.Theyaredividedinto2groupsonthebasisofthelesionsobservedinsucklingmice.

GroupAviruses(23types)produceadiffusemyositiswithacuteinflammationandnecrosisoffibersofvoluntarymuscles.

GroupBviruses(6types)producefocalareasofdegenerationinthebrain,necrosisintheskeletalmuscles,andinflammatorychangesinthedorsalfatpads,thepancreasandoccasionallythemyocardium.

Inaddition,allfromgroupBandonefromgroupA(A9)shareagroupAg.Cross-reactivitieshavealsobeendemonstratedbetweenseveralgroupAvirusesbutnocommongroupantigenhasbeenfound.;Pathogenesis;Myocarditis-groupBcoxsackievirusesarethemajorcauseofmyocarditis,althoughitmaybecausedbyotherenteroviruses.Itmaypresentinneonatesaspartofneonatalinfectionandisoftenfatal.Inadults,thediseaseisrarelyfatal.

RespiratoryInfections-severalenterovirusesareassociatedwiththecommoncold.

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