BRD-6929-Standard-生命科学试剂-MCE.pdfVIP

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BRD-6929(Standard)

Cat.No.:HY-100719R

CASNo.:849234-64-6

分⼦式:C₁₉H₁₇N₃O₂S

分⼦量:351.42

作⽤靶点:HDAC;ReferenceStandards;HIV

作⽤通路:CellCycle/DNADamage;Epigenetics;Others;Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BRD-6929(Standard)是BRD-6929(HY-100719)的分析标准品。本产品⽤于研究及分析应⽤。BRD-6929是I

类组蛋⽩去⼄酰化酶HDAC1和HDAC2的脑渗透性选择性抑制剂(IC50=1和8nM)。BRD-6929对HDAC1和

HDAC2有⾼亲和⼒(Ki=0.2和1.5nM)。BRD-6929可⽤于情绪相关⾏为的研究。

REFERENCES

[1].Li-HueiTsai,etal.Inhibitionofhdac2topromotememory.patent/US20120101147

[2].SchroederFA,etal.AselectiveHDAC1/2inhibitormodulateschromatinandgeneexpressioninbrainandaltersmousebehaviorintwo

mood-relatedtests.PLoSOne.2013Aug14;8(8):e71323.

[3].HuangL,etal.EliminationofHIV-1LatentlyInfectedCellsbyGnidimacrinandaSelectiveHDACInhibitor.ACSMedChemLett.2018

Feb6;9(3):268-273.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.