Darbufelone-mesylate-Standard-生命科学试剂-MCE.pdfVIP

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Darbufelonemesylate(Standard)

Cat.No.:HY-101438AR

CASNo.:139340-56-0

分⼦式:C₁₉H₂₈N₂O₅S₂

分⼦量:428.57

作⽤靶点:ProstaglandinReceptor;ReferenceStandards;Leukotriene

Receptor

作⽤通路:GPCR/GProtein;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Darbufelone(mesylate)(Standard)是Darbufelone(mesylate)(HY-101438A)的分析标准品。本产品⽤于研

究及分析应⽤。Darbufelonemesylate(CI-1004mesylate)双重抑制细胞PGF2α和LTB4产⽣。Darbufelone

有效抑制PGHS-2(IC50=0.19μM)，

IC50TargetIC50:0.19μM(PGHS-2),20μM(PGHS-1)[1]

REFERENCES

[1].JohnsonAR,etal.Slow-bindinginhibitionofhumanprostaglandinendoperoxidesynthase-2withdarbufelone,anisoform-selective

antiinflammatorydi-tert-butylphenol.Biochemistry.2001Jun26;40(25):7736-45.

[2].YeX,etal.Darbufelone,anovelanti-inflammatorydrug,inducesgrowthinhibitionoflungcancercellsbothinvitroandinvivo.Cancer

ChemotherPharmacol.2010Jul;66(2):277-85.

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