N-Desmethyl-clindamycin-hydrochloride-生命科学试剂-MCE.pdfVIP

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N-Desmethylclindamycinhydrochloride

Cat.No.:HY-180469

CASNo.:25532-03-0

分⼦式:C₁₇H₃₂Cl₂N₂O₅S

分⼦量:447.42

作⽤靶点:DrugMetabolite

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性N-Desmethylclindamycinhydrochloride是Clindamycin(HY-B1455)的主要代谢产物。N-Desmethyl

clindamycinhydrochloride对L1210、KB、RPMI6410和RPMI1788癌细胞具有强⼤的细胞毒性，其LD50

值分别为0.07、0.29、0.13和0.32μM。N-Desmethylclindamycinhydrochloride能够抑制细胞的DNA、

RNA和蛋⽩质合成。N-Desmethylclindamycinhydrochloride可⽤于感染和癌症的研究[1]。

REFERENCES

[1].LiLH,etal.Cytotoxicityofseveralmarketedantibioticsonmammaliancellsinculture[J].TheJournalofAntibiotics,1977,30(6):506-

512.

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