Nedisertib-Standard-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Nedisertib(Standard)

Cat.No.:HY-101570R

CASNo.:1637542-33-6

分⼦式:C₂₄H₂₁ClFN₅O₃

分⼦量:481.91

作⽤靶点:DNA-PK;ReferenceStandards;BCRP

作⽤通路:CellCycle/DNADamage;PI3K/Akt/mTOR;Others;Membrane

Transporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Nedisertib(Standard)是Nedisertib(HY-101570)的分析标准品。本产品⽤于研究及分析应⽤。Nedisertib

(Peposertib)是⼀种⼝服有效的选择性DNA依赖性蛋⽩激酶(DNA-PK)抑制剂，IC50值⼩于3nM。

Nedisertib也是ABCG2的调节剂，可逆转ABCG2介导的多药耐药(MDR)，为联合⽤药提供新策略。

Nedisertib可通过

IC50TargetIC50:[3]

REFERENCES

[1].L.Damstrup,etal.M3814,aDNA-dependentProteinKinaseInhibitor(DNA-PKi),PotentiatestheEffectofIonizingRadiation(IR)in

XenotransplantedTumorsinNudeMice.IJROBP.2016;94,940-941.

[2].ThomasFuchss,etal.Arylchinazoline.WO2014183850A1.2014-11-20.

[3].WuZX,etal.M3814,aDNA-PKInhibitor,ModulatesABCG2-MediatedMultidrugResistanceinLungCancerCells.FrontOncol.2020

May12