N-NHS-PEG4-N-PEG4-Val-Cit-PAB-MMAF-N-PEG4-Val-Cit-PAB-Exatecan-生命科学试剂-MCE.pdfVIP

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N-(NHS-PEG4)-N-(PEG4-Val-Cit-PAB-MMAF)-N-(PEG4-Val-Cit-PAB-

Exatecan)

Cat.No.:HY-177688

分⼦式:C₁₃₉H₂₀₃FN₂₀O₄₁

分⼦量:2829.21

作⽤靶点:Drug-LinkerConjugatesforADC;Topoisomerase;

Microtubule/Tubulin

作⽤通路:Antibody-drugConjugate/ADCRelated;CellCycle/DNA

Damage;Cytoskeleton

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性N-(NHS-PEG4)-N-(PEG4-Val-Cit-PAB-MMAF)-N-(PEG4-Val-Cit-PAB-Exatecan)是⼀种⽤于抗体药物偶联物(

ADC)的药物-连接⼦偶联物，由微管蛋⽩聚合抑制剂MMAE(HY-15162)、DNA拓扑异构酶I抑制剂Exatecan

(HY-13631)和ADC连接⼦组合物组成。N-(NHS-PEG4)-N-(PEG4-Val-Cit-PAB-MMAF)-N-(PEG4-Val-Cit-PAB-

Exatecan)可⽤于ADC的合成和癌症研究。

体外研究ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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