N-N-Dimethylsphingosine-13C2-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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N,N-Dimethylsphingosine-13C2

Cat.No.:HY-108491S

分⼦式:C₁₈₁₃C₂H₄₁NO₂

分⼦量:329.53

作⽤靶点:Isotope-LabeledCompounds;SphK

作⽤通路:Others;Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性N,N-Dimethylsphingosine-13C2是13C标记的N,N-Dimethylsphingosine(HY-108491)。N,N-

Dimethylsphingosine是SphK(鞘氨醇激酶)的有效抑制剂，在多种组织和肿瘤细胞系中是鞘氨醇的内源性代

谢产物。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].EndoK,etal.Cellmembranesignalingastargetincancertherapy:inhibitoryeffectofN,N-dimethylandN,N,N-trimethylsphingosine

derivativesoninvitroandinvivogrowthofhumantumorcellsinnudemice.CancerRes.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedfor