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NPT100-18A

Cat.No.:HY-156898

分⼦式:C₂₈H₃₉N₅O₃

分⼦量:493.64

作⽤靶点:α-synuclein;Caspase;ReactiveOxygenSpecies(ROS)

作⽤通路:NeuronalSignaling;Apoptosis;Immunology/Inflammation;

MetabolicEnzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NPT100-18A是⼀种α-突触核蛋⽩寡聚化抑制剂。NPT100-18A可将裂解的caspase-3⽔平恢复⾄正常⽔平。

NPT100-18A以区室特异性的⽅式减弱线粒体氧化应激探针的⽔平，并且在⾼浓度下可增加ATP信号。

NPT100-18A可⽤于帕⾦森病(PD)的研究[1][2]。

IC50TargetCaspase3

体外研究NPT100-18A(10nM)reducestheamountofTriton-X100insolubleαSynaggregatedconformersiniPSC-

derivedmDANs[1].

NPT100-18A(10nM)specificallyreducesmitochondrialROSiniPSC-derivedmDANswithoutaffectingtotal

intracellularROS[1].

NPT100-18A(1µM)significantlyincreasesATPsignalinginiPSC-derivedmDANs[1].

NPT100-18A(10nM,21days)significantlyreducestheproportionofcCasp3neuronsiniPSC-derived

mDANsandinhibitstheαSyn-relatedearlyneuronalapoptosispathway[1].

体内研究NPT100-18A(1-20mg/kg,i.p.,oncedailyfor90days)significantlyimprovedmotordysfunctioni