PF-06764427-生命科学试剂-MCE.pdfVIP

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PF

Cat.No.:HY-123852

CASNo.:1842371-08-7

分⼦式:C₂₄H₂₅N₅O₃

分⼦量:431.49

作⽤靶点:mAChR

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PF是⼀种选择性M1毒蕈碱型⼄酰胆碱受体正向变构调节剂。PF具有显著的M1受体激

动活性。PF可⽤于阿尔茨海默病和精神分裂症的研究。

IC50TargetmAChR1

REFERENCES

[1].DavorenJE,etal.DesignandoptimizationofselectiveazaindoleamideM1positiveallostericmodulators.BioorgMedChemLett.2016

Jan15;26(2):650-655.

[2].MoranSP,etal.M1-positiveallostericmodulatorslackingagonistactivityprovidetheoptimalprofileforenhancingcognition.

Neuropsychopharmacology.2018Jul;43(8):1763-1771.

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