PF-06263276-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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PF(Standard)

Cat.No.:HY-101024R

CASNo.:1421502-62-6

分⼦式:C₃₁H₃₁FN₈O₂

分⼦量:566.63

作⽤靶点:JAK;ReferenceStandards;STAT

作⽤通路:Epigenetics;JAK/STATSignaling;ProteinTyrosine

Kinase/RTK;StemCell/Wnt;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PF(Standard)是PF(HY-101024)的分析标准品。本产品⽤于研究及分析应⽤。PF-

(PF6263276)是⼀种有效、选择性的pan-JAK抑制剂，对JAK1、JAK2、JAK3和TYK2的抑制作⽤

IC50值分别为2.2nM、23.1nM、59.9nM和29.7nM。PF抑制pSTAT3和TYK2

IC50TargetIC50：2.2nM(JAK1),23.1nM(JAK2),59.9nM(JAK3),29.7nM(TYK2)[1]

REFERENCES

[1].JonesP,etal.DesignandSynthesisofaPan-JanusKinaseInhibitorClinicalCandidate(PFSuitableforInhaledandTopical

DeliveryfortheTreatmentofInflammatoryDiseasesoftheLungsandSkin.JMedChem.2017Jan26;60(2):767-786.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.