PF-04979064-Standard-生命科学试剂-MCE.pdfVIP

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PF(Standard)

Cat.No.:HY-100398R

CASNo.:1220699-06-8

分⼦式:C₂₄H₂₆N₆O₃

分⼦量:446.5

作⽤靶点:PI3K;ReferenceStandards;mTOR

作⽤通路:PI3K/Akt/mTOR;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PF(Standard)是PF(HY-100398)的分析标准品。本产品⽤于研究及分析应⽤。PF-

是⼀种有效的选择性PI3K/mTOR双重激酶抑制剂，抑制PI3Kα和mTOR，Ki分别为0.13nM和

1.42nM。

IC50TargetKi:0.13nM(PI3Kα),1.42nM(mTOR)[1]

REFERENCES

[1].ChengHetal.DiscoveryoftheHighlyPotentPI3K/mTORDualInhibitorPFthroughStructure-BasedDrugDesign.ACSMed

ChemLett,2012Nov7,4(1):91-7.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤