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PF(Standard)

Cat.No.:HY-101111R

CASNo.:198474-05-4

分⼦式:C₁₂H₉FN₂O₂

分⼦量:232.21

作⽤靶点:Indoleamine2,3-Dioxygenase(IDO);ReferenceStandards

作⽤通路:MetabolicEnzyme/Protease;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PF(Standard)是PF(HY-101111)的分析标准品。本产品⽤于研究及分析应⽤。PF-

(EOS200271)是⼀种有⼝服活性的，选择性的，可透过⾎脑屏障的IDO-1抑制剂，抑制hIDO-1，

dIDO-1，和mIDO-1的IC50分别为0.41μM，0.59μM，和1.5μM[2]。

REFERENCES

[1].TumangJ,etal.PFahighlyselectiveIDO-1inhibitorthatshowsgoodinvivoefficacyincombinationwithimmune

checkpointinhibitors.[abstract].In:Proceedingsofthe107thAnnualMeetingoftheAmericanAssociationforCancerResearch;2016Apr

16-20;NewOrleans,LA.Philadelphia(PA):AACR;CancerRes2016;76(14Suppl):Abstractnr4863.

[2].Indoleamine2,3-Dioxygenase(IDO-1)Inhibitor3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione(EOS200271/PFandIts

CharacterizationasaPotentialClinicalCandidate.JMedChem.2017Dec1