PF-06745013-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

PF

Cat.No.:HY-123965

CASNo.:2089334-01-8

分⼦式:C₂₁H₁₉ClN₂O₃

分⼦量:382.84

作⽤靶点:MAP4K;TNFReceptor

作⽤通路:MAPK/ERKPathway;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PF(Compound37)是⼀种MAP4K4抑制剂，且不具有CYP3A4的时间依赖性抑制(TDI)风险(对

MAP4K4的IC50为0.4nM)。PF在⼩⿏模型中不具有中枢神经系统损害和⾮ATP竞争性活性。PF-

可⽤于糖尿病等炎症性疾病和癌症的研究[1]。

IC50TargetMAP4K4

0.4nM(IC50)

REFERENCES

[1].DowRL,etal.2-Aminopyridine-BasedMitogen-ActivatedProteinKinaseKinaseKinaseKinase4(MAP4K4)Inhibitors:Assessmentof

Mechanism-BasedSafety.JMedChem.2018Apr12;61(7):3114-3125.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1Master