PF-04991532-Standard-生命科学试剂-MCE.pdfVIP

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PF(Standard)

Cat.No.:HY-100181R

CASNo.:1215197-37-7

分⼦式:C₁₈H₁₉F₃N₄O₃

分⼦量:396.36

作⽤靶点:Glucokinase;ReferenceStandards

作⽤通路:MetabolicEnzyme/Protease;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PF(Standard)是PF(HY-100181)的分析标准品。本产品⽤于研究及分析应⽤。PF-

是⼀种有效的肝选择性葡萄糖激酶激活剂，在⼈类和⼤⿏中的EC50值分别为80和100nM。

IC50TargetEC50:80nM(glucokinaseinhuman),100nM(glucokinaseinrat)[1]

REFERENCES

[1].ErionDM,etal.ThehepatoselectiveglucokinaseactivatorPFameliorateshyperglycemiawithoutcausinghepaticsteatosisin

diabeticrats.PLoSOne.2014May23;9(5):e97139.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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