Rimegepant-hemisulfate-BMS-927711-hemisulfate-生命科学试剂-MCE.pdfVIP

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Rimegepanthemisulfate

Cat.No.:HY-15498B

CASNo.:1642783-82-1

Synonyms:BMS-927711hemisulfate;BHV-3000hemisulfate

分⼦式:C₂₈H₂₈F₂N₆O₃·₁/₂H₂SO₄

分⼦量:583.6

作⽤靶点:CGRPReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Rimegepant(BMS-927711)hemisulfate是⼀种强效、⼝服有效的选择性竞争性降钙素基因相关肽(CGRP)受

体拮抗剂，对hCGRP受体的Ki为0.027nM，IC50为0.14nM。Rimegepanthemisulfate可⽤于偏头痛研究

[1][2][3]。

客户使⽤本产品发表的科研⽂献

•Nature.2025Apr;640(8059):802-810.

•LancetNeurol.2022Mar;21(3):284-294.

•Cell.2025Oct24:S0092-8674(25)01129-8.

•CellMetab.2022Dec6;34(12):1999-2017.e10.

•BrJPharmacol.2024Jan;181(1):142-161.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].LuoG,etal.Discoveryof(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl4-(2-oxo-2,3-

dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate(BMS-927711):anoralcalcitoningene-relatedpeptide(CGRP)antagonistin

clinicaltrialsfortreatingmigraine.JMedChem.2012Dec13;55(23):10644-51.

[2].VladimirCoric,etal.Dualtreatmentofmigraine.WO2022251752.2022-12-29.

[3].BlairHA.Rimegepant:AReviewintheAcuteTrea