替罗非班注射液治疗进展性脑梗死的临床效果分析.pdfVIP

替罗非班注射液治疗进展性脑梗死的临床效果分析.pdf

论著·临床医学JOURNALOFCHINESEANDFOREIGNMEDICINEANDPHARMACYRESEARCH

替罗非班注射液治疗进展性脑梗死的临床效果分析

顾嘉晨

201700复旦大学附属中山医院青浦分院神经内科，上海

doi:10.3969/j.issn.1007-6229.2025.27.020

摘要目的：探讨替罗非班注射液治疗进展性脑梗死的效果。方法：选取2022年4月—2024年5月复旦大学附属中山

医院青浦分院收治的68例进展性脑梗死患者为研究对象，采用随机数表法分组，对照组34例接受基础药物治疗，观察组

34例在对照组基础上联合替罗非班注射液治疗。比较两组患者临床疗效、凝血功能指标、脑组织平均血流速度及不良反

应情况。结果：观察组治疗总有效率高于对照组（P=0.040）；观察组治疗后凝血酶原时间、活化部分凝血活酶时间均长于

对照组（P＜0.05）；观察组治疗后大脑中、前、后动脉平均血流速度大于对照组（P＜0.05）；两组不良反应发生率无统计学

差异（P＞0.05）。结论：替罗非班注射液治疗进展性脑梗死的效果较好，可有效改善凝血功能与脑组织平均血流速度，且

不会增加不良反应发生风险。

关键词进展性脑梗死；替罗非班注射液；凝血功能

中图分类号R743.33文献标识码A

ClinicalEffectofTirofibanInjectionintheTreatmentofProgressiveCerebralInfarction

GuJiachen

DepartmentofNeurology,QingpuBranchofZhongshanHospitalAffiliatedtoFudanUniversity,Shanghai201700,China

AbstractObjective:Toexploretheeffectoftirofibaninjectioninthetreatmentofprogressivecerebralinfarction.Methods:A

totalofsixty-eightpatientswithprogressivecerebralinfarctionadmittedtoQingpuBranchofZhongshanHospitalAffiliatedto

FudanUniversityfromApril2022toMay2024wereselectedastheresearchobjectsandgroupedbyrandomnumbertable

method.Inthecontrolgroup,thirty-fourcasesreceivedbasicdrugtreatment,whileintheobservationgroup,thirty-fourcases

weretreatedwithtirofibaninjectionincombinationwiththecontrolgroup.Theclinicalefficacy,coagulationfunctionindicators,

averagebloodflowvelocityofbraintissueandadversereactionsofthetwogroupsofpatientswerecompared.Results:Thetotal

effectiverateoftreatmentintheobservationgroupwashigherthanthatinthecontrolgroup(P=0.040).Aftertreatment,the

prothrombintimeandactivatedpartialthromboplastintimeintheobservationgroupwerelongerthanthoseinthecontrolgroup

(P0.05).Aftertreatment,theaveragebloodflowvelocitiesofthemiddle,anteriorandposteriorarteriesintheobservationgroup