病理学英文版课件_淋巴造血系统疾病The_Lymphohem_atopoietic_Systems_.pptVIP

d popcorn cell popcorn cell 1.nodular sclerosis 2.mixed-cellularity 3.lymphocyte predominance 4.lymphocyte deplesion 4.lymphocyte depletion: (1) very rare (2) lymphocytes---depleted (3) RS cell follicular  lymphoma NHL:B cell neoplasms 1 Morphology: follicular centrocytes and centroblast-  like cell a high mitotic rate follicular lymphoma follicular lymphoma * The Lymphohematopoietic Systems Chapter 9 Zhou Hongyan Lymphohematopoietic system: myeloid tissue lymphoid tissue nomal lymph node follicular LYMPHOID NEOPLASMS Arise in bone marrow and circulate in the peripheral blood . Appear as tumor masses within either lymph nodes or other organs. relevant principles: 1.Most lymphoid neoplasms(80%- 85%) are of B-cell origin. 2. The normal architecture of the lymph nodes is effaced. 3. Disrupt normal immune regulatory mechanism. 4.Monoclonal neoplasms. 5.NHL---widely disseminated at the time of diagnosis. HL—spreads methodically to contiguous lymph node groups. relevant principles: Classification:(REAL and WHO) three major categories: (1)tumors of B cells (2)tumors of T cells and NK cells (3)Hodgkin lymphoma LYMPHOID NEOPLASMS: Hodgkin lymphoma --------- (HL) non - Hodgkin lymphoma --------- (NHL) Hodgkin lymphoma HL: Hodgkin lymphoma: 1.It arises almost invariably in a single node or a chain of nodes and spreads characteristically to the anatomically contiguous nodes. Hodgkin lymphoma 2. Reed-Sternberg(R-S) cell which are admixed with a variable infiltrate of reactive, non-malignant inflammatory cells. mirror-image cell Classification: 1.nodular sclerosis 2.mixed-cellularity 3.lymphocyte predominance 4.lymphocyte deplesion 1.nodular sclerosis 2.mixed-cellularity 3.lymphocyte predominance 4.lymphocyte deplesion 1.nodular sclerosis ⑴ lacunar cell ⑵ collagen bands divide the lymphoid tissue into circumscribed nodules ⑴ lacunar cell: This cell is large and has