病理学课件_中枢系统肿瘤.pptVIP

§5 Alzheimer’s disease ;Alzheimer’s disease （AD);Alzheimer’s disease 病 因 发 病;? ? ?;Alzheimer’s disease 病 理 变 化;In this case of Alzheimers disease, there is more marked atrophy seen superiorly and laterally, with sparing of the occipital region. ;神经原纤维缠结;Neurofibrillary change Ag impregnation;Senile plaque; Primary intracranial tumor: Glioma 胶质瘤（40%） Meningioma 脑膜瘤（15%） Acoustic neurinoma 听神经瘤（8%） Metastatic tumors: lung, breast ; Size, location nature Local effect General effect; Differentiation分化 Clinical progression Genetic changes;atypia, mitotic rate, capillary, endothelial cells, necrosis, hemorrhage;P53 mutation / loss of chr. 17p Loss of chr.22q Rb mutation / loss of chr.13q P16 deletion / loss of chr.3p Loss of chr.19q Loss of ch.10 EGFR gene amplification;astrocytoma;;Astrocytoma ;Glioblatona multiforme;Giant cells in glioblastoma multiforme;Giant cells in glioblastoma multiforme;Giant cells in glioblastoma multiforme, IH GFAP;Pseudopalisading (glioblastoma multiforme);Endothelial cell proliferation glioblastoma multiforme; 20y Cerebellum Primitive undifferentiated cell small tumor cells, scanty cytoplasm rosette 菊形团 Seeding through CSF Highly malignant;Medulloblastoma ;;Seeding of medulloblastoma; From : arachnoid cell 蛛网膜细胞 部位 : ~ arachnoid granulation dura 硬脑膜 大体：solid, gritty 砂粒样 光镜：whorl-like pattern psammoma砂粒体 Malignant: rare;meningioma;Here is another benign meningioma beneath the dura. These neoplasms are slow growing, but may reach a large size before symptoms lead to detection.;Meningioma of sphenoid wing;;;; From: Schwann cell 大体: encapsulated, solitary ~ nerves, spinal roots 光镜: Spindle tumor cells, 排列成 束状，网状 Benign;Acoustic schwannoma;Schwannoma of a spinal root ;Acoustic schwannoma;Gemistocytix astrocytoma;Gemistocytix astr