病理学英文课件_Chapter_5_Neoplasia5.4TumorMetabolism_.pptVIP

Section 3 The Characteristic Of Tumor Metabolism More vigorous in quantity but no difference in nature compared with normal cells. 1. Tumor nucleic acid metabolism Synthesize decompose ( offered by Dr. Song J. Xin) (2) Tumor associated antigen (TAA) Express increasingly in tumor cells. ① Viral antigens ET: Peptides derived from the HPV-16 ② Embryonic antigens: a. α-fetoprotein (AFP) b. carcinoembryonic antigen(CEA) ③ Differentiation antigens: CD10 (CALLA antigen): an antigen expressed in early B lymphocytes, also expressed in B-cell leukemias. 3. Enzyme system not find special tumor enzymes (1) proliferation asscoated enzymes DNA polymerase more active in malignant tumor (2) Transform associated enzymes: mark of malignant but not compare with malignant degree (3) Development associated enzymes The activity compare with malignant degree. (4) Biotransformation enzymes (5) Change of isozymogram GST-P the earliest mark of rat livener cancer * * 2. Protein metabolism Synthesize decompose Cachexia: extremely thin, anemia, and weak. (1) Tumor specific antigen (TSA): Only expressed in tumor cells, not exist in normal cells.