冠状动脉硬化与HCMV.doc免费

冠状动脉粥样硬化与人巨细胞病毒 感染关系的临床研究 王震 李海滨 刘坤申 【摘要】目的 探讨动脉粥样硬化与人巨细胞病毒(HCMV)感染的关系。方法 对102例胸痛患者进行选择性冠状动脉造影，按冠状动脉狭窄程度分为正常对照组28例、病变组74例（单支病变组32例、两支及以上病变组42例）。应用酶联免疫吸附技术检测各组血清HCMV-IgM抗体，并对各组指标进行统计学分析及直线相关分析。结果 正常对照组28例中HCMV-IgM抗体阳性4例（14.28%），病变组74例中阳性32例（43.24%），两组比较差异有显著意义(Ｐ0.05)；且两支及以上病变组HCMV-IgM抗体阳性率（57.14%）明显高于单支病变组（25%）(Ｐ0.05)。HCMV-IgM阳性患者冠脉积分明显高HCMV-IgM阴性患者（P0.005）；结论 巨细胞病毒感染与冠状动脉粥样硬化之间关系密切。 【关键词】巨细胞病毒；冠状动脉粥样硬化 Relationship between coronary atherosclerosis and the infection of human cytomegalovirus Wangzhen,LI Hai-bin,LIU Kun-shen The First Hospital of Hebei Medical University,Shijiazhuang 050031,China ABSTRACT：Obective To investigate the relationship between coronary atherosclerosis and the infection of human cytomegalovirus(HCMV). Methods One hundred and two patients were enrolled into this study.All the patients underwent coronary atherosclerosis and their serum HCMV-IgM were measured by enzyme-linked immunosorbent assay (ELISA).The patients were divided into two groups according to the severity of coronary artery stenosis,28 with normo- coronary artery and 74 with abnormo- coronary artery. Result The positive rato of HCMV-IgM were singnificantly higher in patients with coronary artery disease than those in the normal subjects(43.24% vs 14.28%), and more than two vessel disease group were singnificantly higher in patients with one vessel disease group(57.14% vs 25%). The mark of coronary artery of the positive patients of HCMV-IgM were singnificantly higher than those negative patients（P0.005）. Consulsion The relationship is close between coronary atherosclerosis and the infection of human cytomegalovirus(HCMV). 动脉粥样硬化是严重危害人类健康的常见病,其确切病因与发病机理尚未完全阐明。近年来研究发现病毒感染与动脉粥样硬化的发生密切相关，尤其是人类巨细胞病毒（Human Cytomegalovirus, HCMV）感染越来越引起人们的重视，发现HCMV与冠心病的发生有一定关系[1]。本研究选择了102例可疑冠心病而行选择性冠状动脉造影术患者，同时采用酶联免疫吸附法（ELISA）检测HCMV-IgM抗体，以探讨HCMV感染在冠状动脉粥样硬化发生中的作用及与冠状动脉病变的关系。 1 资料与方法 1.1 一般资料 选取我院2002年3月—2004年1月102例胸痛住院的患者，男性74例，女性28例，平均年龄（62.7±9.8）岁；其中合并高血压患者56例，吸烟52例。所有患者过去均无确诊的冠